Control of coronary vascular resistance by eicosanoids via a novel GPCR

NJ Alkayed, Z Cao, ZY Qian… - … of Physiology-Cell …, 2022 - journals.physiology.org
… 39 (GPR39) as a microvascular smooth muscle cell (mVSMC) … us to isolate its binding proteins
from mouse heart mVSMCs … -activated (BKCa) and ATP-sensitive potassium channels, the …

Reactive oxygen species in cardiovascular health and disease: special references to nitric oxide, hydrogen peroxide, and Rho-kinase

H Shimokawa - Journal of Clinical Biochemistry and Nutrition, 2020 - jstage.jst.go.jp
… the tonus of underlying vascular smooth muscle cells (VSMC) by … RhoA is activated by the
guanine nucleotide exchange … The small GTP-binding protein Rho binds to and activates a …

[HTML][HTML] The calcium signaling mechanisms in arterial smooth muscle and endothelial cells

M Ottolini, SK Sonkusare - Comprehensive Physiology, 2021 - ncbi.nlm.nih.gov
… Ca 2+ is increased by ion channels and transporters on the … This article focuses on endothelial
and smooth muscle Ca 2+ … of abnormal endothelial and smooth muscle Ca 2+ signals to …

The involvement of soluble epoxide hydrolase in the development of cardiovascular diseases through epoxyeicosatrienoic acids

S Jiang, S Han, DW Wang - Frontiers in Pharmacology, 2024 - frontiersin.org
… epoxides, binding to fatty acid binding protein, and binding to cell … through the activation of
KCa in vascular smooth muscle … of cardiac ion channels such as KATP, L-type Ca2+ channels

The epoxy fatty acid pathway enhances cAMP in mammalian cells through multiple mechanisms

N Matsumoto, N Singh, KS Lee, B Barnych… - Prostaglandins & other …, 2022 - Elsevier
… The epoxyeicosatrienoic acids (EETs), EpFAs produced from … 11,12-EET activates the BK
Ca channel through the action of … We demonstrated that coronary artery smooth muscle cells …

Recent advances in understanding the mechanistic role of transient receptor potential ion channels in hypertension.

FJ Rios, RD Sarafian, LL Camargo… - Canadian Journal of …, 2023 - Elsevier
activated by TRP channels in vascular smooth muscle and … structural domain of calcium-binding
proteins; ER retention – … 11,12-epoxyeicosatrienoic acid by mechanisms dependent …

Prostaglandin and prostaglandin receptors: present and future promising therapeutic targets for pulmonary arterial hypertension

C Zeng, J Liu, X Zheng, X Hu, Y He - Respiratory Research, 2023 - Springer
… , and the six-minute walk distance, cardiac output and exercise capacity and are licensed
for … development of PAH through vasoconstriction, vascular smooth muscle cell proliferation …

Epoxyeicosatrienoic acid and prostanoid crosstalk at the receptor and intracellular signaling levels to maintain vascular tone

PF Malacarne, J Bezzenberger, M Lopez… - International Journal of …, 2022 - mdpi.com
… The direct effects of PG on the tone of smooth muscle cells (… -conductance Ca 2+ -activated
K + channels and/or transient … that EETs bind to GPCR (guanine nucleotide-binding protein-…

[PDF][PDF] The Physiological Mechanism of Extracellular CalciumSensing Receptor Action in the Regulation of Vascular Tone and Blood Pressure

L Melaku, B Elias - Biomedical Journal of Scientific & Technical …, 2023 - researchgate.net
… transmission, muscle contraction, cardiac automaticity, nerve … the epoxygenase pathway to
form epoxyeicosatrienoic acids … endothelium and activates BKCa on the smooth muscle cells. …

Brain capillary pericytes and neurovascular coupling

S Grubb, M Lauritzen, C Aalkjær - … and Physiology Part A: Molecular & …, 2021 - Elsevier
guanine nucleotide exchange factor … Here we use the term “mural cells” to cover both vascular
smooth muscle cells and … constricts through α-adrenergic receptor activation and relaxes …